Animal models in bicompatibility assessments of implants in soft and hard tissues

The ethical dilemmas of using animals as in vivo models preclinical and clinical examinations have been increasingly present recent decades. Small laboratory (rats, rabbits) will continue to be used because they are cost-effective permit the formation statistically testable cohort groups; a task that, for financial, maintenance care reasons, is almost prohibitive larger animals. Technological advances production new biomaterials use enormous, but screening tests methods assess biocompatibility lag behind these advances. assessment biological responses slow based on millennial recovery mechanisms eukaryotic organisms. Therefore, goal researchers this field re-evaluate old introduce evaluation, especially testing. In that sense, revision ISO standards was planned conducted 2017, which insisted cytotoxicity testing cell lines produced concrete proposals how should quantified. evaluation soft tissue commonly utilises rats. Rabbits recommended implants hard tissues, rabbit?s size, possibility implanting bone surface, peculiarities rabbit favours rapid after defects enables easy reading results